In a recent article published in NANOMEDICINEVOL. 15, NO. 1 the authors described the results of an investigation into the effect of cerium oxide nanoparticles (nanoceria) on psoriasis.
Results: Nanoceria significantly attenuated splenic hypertrophy, psoriasis area severity index scoring, and lipid peroxidation. It also reduced the expression of various inflammatory and proliferation markers such as IL-17, IL-22, IL-23, Ki-67, NF-κB, COX-2 and GSK3.
Conclusion: Nanoceria exerts an antipsoriatic effect by inhibiting major pathogenic immune axes namely the Th-cell mediated IL-17/IL-23 axis and by downregulating other crucial inflammatory proteins like NF-κB, COX-2 and GSK3.
Akshara Domala‡, Swarna Bale‡ & Chandraiah Godugu
Published Online: 23 Dec 2019 https://doi.org/10.2217/nnm-2018-0515